Nanoscale functional materials and devices for biomedical applications
Our mission is to develop the next generation of materials, tools and methods for biomedicine using core engineering sciences. Our approach is highly multidisciplinary bringing expertise from material and process engineering to health sciences. This allows for the design and engineering of biomaterials that exhibit the desired functionality in applications ranging from diagnostics to therapeutic interventions.
We focus on scalable flame aerosol manufacturing (using a flame spray pyrolysis reactor, shown right) of smart nanoscale materials and devices and tune their properties, targeting superior performance in theranostics.
The focus of our research program at KI lies on studying the physicochemical properties of nanomaterials made by aerosol processes and then applying this fundamental understanding to tailor functional particles and particle-enabled devices for diagnosis and precision therapies of diseases. The three main research pillars of our lab regard the (i) nanoparticle engineering for in vitro and in vivo diagnostics, (ii) the fabrication of medical devices capitalizing on aerosol nanoparticle self-assembly on surfaces combining particle synthesis and particle film fabrication in a single-step, and (iii) the utilization of nanoparticles as drug nanocarriers.
WE GRATEFULLY ACKNOWLEDGE OUR FUNDING:
- Karolinska Institutet, StratRegen Research Grant, 2021.
- Ögonfonden (Eye Foundation) Research Grant, 2021.
- European Research Council, ERC Proof of Concept Grant 2021.
- Swedish Foundation for Strategic Research (SSF), Future Research Leaders Grant 2020.
- Marie Skłodowska-Curie Individual Fellowship (coordinator as host) 2020.
- Karolinska Institutet Faculty Board, Faculty Funded Career Position, 2019.
- Swedish Foundation for Strategic Research (SSF), Med-X Grant 2019.
- Torsten Söderberg Foundation, Medicine Grant 2018.
- Swedish Research Council (Vetenskapsrådet), Research Environment Grant 2018.
- Swedish Foundation for Strategic Research, Instrumentation Grant (with J. Widengren from KTH) 2018.
- Loo and Hans Osterman Foundation, Research Grant 2018.
- European Research Council, ERC Starting Grant 2017.
- Swedish Research Council (Vetenskapsrådet), Starting Grant 2016.
- Åke Wiberg Foundation, Grant for Medical Research, 2016.
- The Jeansson Foundations, Grant for Medical Research 2016.
- KI Foundation, Research Grants 2016-2018.
- Karolinska Institutet Board of Research Strategic Funding.
NanoBiomaterials for therapeutics
We produce nanoscale materials and employ them either as standalone therapeutic compounds, or as functional components in multiscale architectures. Specific focus areas are (i) antimicrobial nanoparticles and (ii) stimuli-responsive nanoparticles (plasmonic, superparamagnetic) aiming their integration in smart medical devices.
Novel diagnostic tools and devices
Here we focus on the fabrication of responsive materials that can be employed in diagnosis either as biosensors (e.g. for specific analyte detection), or as bioimaging agents (e.g. luminescent materials for in vitro bioimaging, MRI contrast agents for in vivo bioimaging). We systematically study the physicochemical properties that govern their performance, placing specific emphasis in robustness and reproducibility.